Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype

J Autism Dev Disord. 2023 May;53(5):1906-1914. doi: 10.1007/s10803-022-05466-6. Epub 2022 Feb 7.

Abstract

Pre- and post-term children show increased autism risk. Little is known about gestational age (GA) prevalence among autistic children, and their respective autism phenotype. We compared prevalence of pre-, full- and post-term birth between a population-derived sample of N = 606 (137 females, 22.61%) autistic children and adolescents (mean age = 14.01, SD = 3.63, range 3-24) from the Netherlands Autism Register, and matched controls from the Dutch birth register. Autism phenotype and comorbid symptoms were assessed with the AQ-short and SDQ questionnaires. Using logistic regression, we found higher prevalence of pre- and post-term birth among autistic individuals but no phenotypical differences across GA groups. Autism risk was particularly elevated for post-term children, highlighting the need for closer investigation of autism on the whole GA range.

Keywords: Autism phenotype; Autism spectrum disorders; Post-term birth; Preterm birth.

MeSH terms

  • Autism Spectrum Disorder*
  • Autistic Disorder* / epidemiology
  • Autistic Disorder* / genetics
  • Child
  • Female
  • Gestational Age
  • Humans
  • Phenotype
  • Prevalence