The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate

Pediatr Pulmonol. Jan-Feb 1986;2(1):9-14. doi: 10.1002/ppul.1950020106.

Abstract

Lung function was measured in nine infants, ages 15-36 weeks, who had persistent wheezing, apparently following acute bronchiolitis, before and after 2 weeks of treatment with either inhaled nebulized beclomethasone dipropionate (BDP) or placebo in a randomized, double blind, crossover trial. The effect of nebulized albuterol (Salbutamol) was measured before and after the steroid treatment. Thoracic gas volume (TGV) and specific airway conductance (SGaw) were determined using a whole body plethysmograph, and forced expiratory flow at resting lung volume (VmaxFRC) was determined with a thoracoabdominal compression jacket. All infants had marked airways obstruction before treatment with mean +/- SE VmaxFRC of 24 +/- 4% predicted and SGaw of 37 +/- 5% predicted. Two weeks of placebo treatment had no significant effect on lung function, but after 2 weeks of BDP inhalation there was a significant rise in SGaw to 61 +/- 7% (P less than 0.005). VmaxFRC increased to 42 +/- 13% but the difference did not reach significance. Respiratory rate and clinical score for retractions and wheezing also fell significantly with BDP therapy (P less than 0.01 and P less than 0.001 respectively). Albuterol had no effect on lung function either before or during steroid therapy. Steroids may have a role in the management of persistent wheezing following bronchiolitis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intranasal
  • Airway Resistance
  • Albuterol / administration & dosage
  • Albuterol / therapeutic use
  • Beclomethasone / administration & dosage*
  • Beclomethasone / therapeutic use
  • Bronchiolitis, Viral / complications
  • Bronchiolitis, Viral / drug therapy*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Infant
  • Lung / physiopathology*
  • Male
  • Maximal Expiratory Flow-Volume Curves
  • Placebos
  • Random Allocation
  • Respiratory Function Tests
  • Respiratory Sounds / etiology*
  • Volatilization

Substances

  • Placebos
  • Beclomethasone
  • Albuterol