Cell types of origin of the cell-free transcriptome

Nat Biotechnol. 2022 Jun;40(6):855-861. doi: 10.1038/s41587-021-01188-9. Epub 2022 Feb 7.


Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell-Free Nucleic Acids*
  • Humans
  • Transcriptome* / genetics


  • Cell-Free Nucleic Acids