Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion

Intern Med. 2022 Sep 1;61(17):2671-2675. doi: 10.2169/internalmedicine.8473-21. Epub 2022 Feb 8.


Pleural effusion is a rare manifestation in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, which is characterized by the presence of osteoarticular lesions and dermatological involvement. We herein report a 71-year-old man with pleural effusion resulting from SAPHO syndrome. He was successfully treated using corticosteroids and has experienced no recurrence for one year. We should consider SAPHO syndrome when encountering cases of anterior chest pain and pleural fluid.

Keywords: SAPHO syndrome; anterior chest pain; hypoxia; pleural effusion.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris* / pathology
  • Acquired Hyperostosis Syndrome* / complications
  • Acquired Hyperostosis Syndrome* / diagnosis
  • Acquired Hyperostosis Syndrome* / drug therapy
  • Aged
  • Humans
  • Hyperostosis* / pathology
  • Male
  • Osteitis* / pathology
  • Pleural Effusion* / diagnostic imaging
  • Pleural Effusion* / etiology
  • Synovitis* / diagnosis
  • Synovitis* / diagnostic imaging