The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

Katherine R Long; Wieland B Huttner

doi:10.3389/fncel.2021.804649

The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

Front Cell Neurosci. 2022 Jan 24:15:804649. doi: 10.3389/fncel.2021.804649. eCollection 2021.

Authors

Katherine R Long^{1

2}, Wieland B Huttner³

Affiliations

¹ Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
² MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom.
³ Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Abstract

Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood. In this review we discuss the role of the ECM in human neocortex development and the different model systems that can be used to investigate this. In particular, we will focus on how the ECM regulates human neural stem and progenitor cell proliferation and differentiation, how the ECM regulates the architecture of the developing human neocortex and the effect of mutations in ECM and ECM-associated genes in neurodevelopmental disorders.

Keywords: development; extracelluar matrix; human; neocortex; neural progenitor.

Publication types

Review

Abstract

Publication types

Grants and funding