Autoimmune polyglandular syndrome type 3: A case report of an unusual presentation and literature review

Michael Apolinario; Aaron Brussels; Curtiss B Cook; Shaun Yang

doi:10.1002/ccr3.5391

Autoimmune polyglandular syndrome type 3: A case report of an unusual presentation and literature review

Clin Case Rep. 2022 Feb 4;10(2):e05391. doi: 10.1002/ccr3.5391. eCollection 2022 Feb.

Authors

Michael Apolinario¹, Aaron Brussels², Curtiss B Cook³, Shaun Yang⁴

Affiliations

¹ Department of Internal Medicine Mayo Clinic College of Medicine and Science Scottsdale Arizona USA.
² Department of Anesthesiology and Perioperative Medicine Mayo Clinic College of Medicine and Science Scottsdale Arizona USA.
³ Division of Endocrinology Department of Internal Medicine Mayo Clinic College of Medicine and Science Scottsdale Arizona USA.
⁴ Division of Hospital Internal Medicine Department of Internal Medicine Mayo Clinic College of Medicine and Science Scottsdale Arizona USA.

Abstract

Autoimmune polyglandular syndromes (APS) are rare disorders characterized by auto-destruction of endocrine and non-endocrine organs by organ-specific antibody-directed T-lymphocytic infiltration. This case highlights a 29-year-old Caucasian man with vitiligo found to have significant neurological abnormalities in the setting of newly diagnosed pernicious anemia and thyroid autoimmune disease.

Keywords: autoimmune polyglandular syndrome; cobalamin deficiency; pernicious anemia; subacute combined degeneration; thyroid autoimmune disease; vitamin B12 deficiency.

Publication types

Case Reports