Twelve-Month Follow-up of Early COVID-19 Cases in the United States: Cellular and Humoral Immune Longevity

Open Forum Infect Dis. 2022 Jan 5;9(3):ofab664. doi: 10.1093/ofid/ofab664. eCollection 2022 Mar.


We quantify antibody and memory B-cell responses to severe acute respiratory syndrome coronavirus 2 at 6 and 12 months postinfection among 7 unvaccinated US coronavirus disease 2019 cases. All had detectable S-specific memory B cells and immunoglobulin G at both time points, with geometric mean titers of 117.2 BAU/mL and 84.0 BAU/mL at 6 and 12 months, respectively.

Keywords: COVID-19; SARS-CoV-2 infection; immunity; memory B cells.