Aspergillus tracheobronchitis in COVID-19 patients with acute respiratory distress syndrome: a cohort study

Philipp Koehler; Saskia von Stillfried; Jorge Garcia Borrega; Frieder Fuchs; Jon Salmanton-García; Fabian Pult; Boris Böll; Dennis A Eichenauer; Alexander Shimabukuro-Vornhagen; Oliver Kurzai; Peter Boor; Matthias Kochanek; Oliver A Cornely

doi:10.1183/13993003.03142-2021

Aspergillus tracheobronchitis in COVID-19 patients with acute respiratory distress syndrome: a cohort study

Eur Respir J. 2022 May 5;59(5):2103142. doi: 10.1183/13993003.03142-2021. Print 2022 May.

Authors

Philipp Koehler^{1

2}, Saskia von Stillfried³, Jorge Garcia Borrega⁴, Frieder Fuchs⁵, Jon Salmanton-García^{4

2}, Fabian Pult^{4

2}, Boris Böll⁴, Dennis A Eichenauer⁴, Alexander Shimabukuro-Vornhagen⁴, Oliver Kurzai^{6

7}, Peter Boor^{3

8}, Matthias Kochanek^{4

9}, Oliver A Cornely^{4

2

10

11

9}

Affiliations

¹ Dept I of Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany philipp.koehler@uk-koeln.de.
² Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
³ Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
⁴ Dept I of Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
⁵ University of Cologne, Medical Faculty and University Hospital Cologne, Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
⁶ Institute for Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany.
⁷ National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, Jena, Germany.
⁸ Dept of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
⁹ M. Kochanek and O.A. Cornely share last authorship.
¹⁰ Clinical Trials Centre Cologne, ZKS Köln, Cologne, Germany.
¹¹ University of Cologne, Medical Faculty and University Hospital Cologne, German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

Abstract

Comprehensive work-up is needed for COVID-19 ARDS patients, especially when suspecting invasive fungal infections. Aspergillus tracheobronchitis has a substantial prevalence in patients with CAPA accounting for an overall mortality of 75% in this study. https://bit.ly/3uF3FZU

Trial registration: ClinicalTrials.gov NCT01731353.

Publication types

Letter

MeSH terms

Aspergillosis*
Aspergillus
Bronchitis* / complications
COVID-19* / complications
Cohort Studies
Humans
Respiratory Distress Syndrome* / complications
Tracheitis* / complications

Associated data

ClinicalTrials.gov/NCT01731353