Role of mitochondria DNA A10398G polymorphism on development of Parkinson's disease: A PRISMA-compliant meta-analysis

J Clin Lab Anal. 2022 Mar;36(3):e24274. doi: 10.1002/jcla.24274. Epub 2022 Feb 11.

Abstract

Background: Parkinson's disease (PD) is characterized by memory loss and multiple cognitive disorders caused primarily by neurodegeneration. However, the preventative effects of the mitochondrial A10398G DNA polymorphism remain controversial. This meta-analysis comprehensively assessed evidence on the influence of the mitochondrial DNA A10398G variant on PD development.

Methods: The PubMed, EMBASE, EBSCO, Springer Link, and Web of Science databases were searched from inception to May 31, 2020. We used a pooled model with random effects to explore the effect of A10398G on the development of PD. Stata MP version 14.0 was used to calculate the odds ratios and 95% confidence intervals (CIs) from the eligible studies to assess the impact of mitochondrial DNA A10398G on PD development.

Results: The overall survey of the populations showed no significant association between mitochondrial DNA A10398G polymorphism (G allele compared to A allele) and PD (odds ratio = 0.85, 95% CI = 0.70-1.04, p = 0.111); however, a significant association between the mutation and PD was observed in the Caucasian population (odds ratio = 0.71, 95% CI = 0.58-0.87, p = 0.001). A neutral effect was observed in the Asian population (odds ratio = 1.10, 95% CI = 0.94-1.28, p = 0.242).

Conclusions: The results of this meta-analysis showed the potential protective effect of the mitochondrial DNA A10398G polymorphism on the risk of developing PD in the Caucasian population. Studies with better designs and larger samples with intensive work are required to validate these results.

Keywords: Parkinson's disease; allele; mitochondrial DNA; neurogenesis.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Asians
  • DNA, Mitochondrial / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mitochondria / genetics
  • Parkinson Disease* / genetics
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide / genetics

Substances

  • DNA, Mitochondrial