Prolonged ST segment and T-wave alternans with torsade de pointes secondary to hypocalcemia due to hypoparathyroidism: A case report

Ann Noninvasive Electrocardiol. 2022 Jul;27(4):e12939. doi: 10.1111/anec.12939. Epub 2022 Feb 11.


Hypoparathyroidism predisposes patients to hypocalcemia. Patients with hypoparathyroidism are thus at risk of electrocardiographic abnormalities, including T-wave alternans. T-wave alternans is poorly understood and lacks uniform diagnostic criteria. Its presence suggests myocardial electrical instability, and it has become an important sign for identifying patients at high risk of malignant arrhythmias and sudden cardiac death. We report a rare case of T-wave alternans with torsade de pointes due to hypocalcemia. The etiology of T-wave alternans may easily be overlooked. It should thus be thoroughly investigated to avoid misdiagnosis and poor outcomes.

Keywords: T-wave alternans; hypocalcemia; hypoparathyroidism; torsade de pointes.

Publication types

  • Case Reports

MeSH terms

  • Arrhythmias, Cardiac / complications
  • Electrocardiography / adverse effects
  • Humans
  • Hypocalcemia* / complications
  • Hypocalcemia* / diagnosis
  • Hypoparathyroidism* / complications
  • Hypoparathyroidism* / diagnosis
  • Torsades de Pointes* / complications
  • Torsades de Pointes* / diagnosis