FGF-FGFR signaling promotes the development of invasive cervical cancer

FEBS J. 2022 Jun;289(12):3419-3421. doi: 10.1111/febs.16384. Epub 2022 Feb 11.


Cervical cancer is one of the most frequently diagnosed gynecological malignancies among women worldwide. The main cause of cervical cancer is the human papilloma virus (HPV). Mahmood et al. investigated in detail the role of the fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling axis in the development of the invasive form of the disease. The presented work clearly indicates the FGFR signaling as an additional but important factor for the development of a highly malignant tumor. Comment on https://doi.org/10.1111/febs.16331.

Keywords: FGF-FGFR signaling; HPV; cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / metabolism
  • Humans
  • Receptor, Fibroblast Growth Factor, Type 1 / genetics
  • Receptor, Fibroblast Growth Factor, Type 1 / metabolism
  • Receptors, Fibroblast Growth Factor* / genetics
  • Signal Transduction
  • Uterine Cervical Neoplasms* / genetics


  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Receptor, Fibroblast Growth Factor, Type 1