FGF-FGFR signaling promotes the development of invasive cervical cancer

Duarte Mateus; Antoni Wiedlocha

doi:10.1111/febs.16384

FGF-FGFR signaling promotes the development of invasive cervical cancer

FEBS J. 2022 Jun;289(12):3419-3421. doi: 10.1111/febs.16384. Epub 2022 Feb 11.

Authors

Duarte Mateus^{1

2}, Antoni Wiedlocha^{1

2}

Affiliations

¹ Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Norway.
² Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, Norway.

PMID: 35146913
DOI: 10.1111/febs.16384

Abstract

Cervical cancer is one of the most frequently diagnosed gynecological malignancies among women worldwide. The main cause of cervical cancer is the human papilloma virus (HPV). Mahmood et al. investigated in detail the role of the fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling axis in the development of the invasive form of the disease. The presented work clearly indicates the FGFR signaling as an additional but important factor for the development of a highly malignant tumor. Comment on https://doi.org/10.1111/febs.16331.

Keywords: FGF-FGFR signaling; HPV; cervical cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Fibroblast Growth Factors / genetics
Fibroblast Growth Factors / metabolism
Humans
Receptor, Fibroblast Growth Factor, Type 1 / genetics
Receptor, Fibroblast Growth Factor, Type 1 / metabolism
Receptors, Fibroblast Growth Factor* / genetics
Signal Transduction
Uterine Cervical Neoplasms* / genetics

Substances

Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors
Receptor, Fibroblast Growth Factor, Type 1