Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations

Yu Toyoda; Akiyoshi Nakayama; Masahiro Nakatochi; Yusuke Kawamura; Hirofumi Nakaoka; Ken Yamamoto; Seiko Shimizu; Hiroshi Ooyama; Keiko Ooyama; Toru Shimizu; Mitsuo Nagase; Yuji Hidaka; Kimiyoshi Ichida; Ituro Inoue; Nariyoshi Shinomiya; Hirotaka Matsuo; Japan Gout Genomics Consortium (Japan Gout)

doi:10.1016/j.ymgme.2022.01.100

Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations

Mol Genet Metab. 2022 Jul;136(3):186-189. doi: 10.1016/j.ymgme.2022.01.100. Epub 2022 Jan 31.

Authors

Yu Toyoda¹, Akiyoshi Nakayama¹, Masahiro Nakatochi², Yusuke Kawamura¹, Hirofumi Nakaoka³, Ken Yamamoto⁴, Seiko Shimizu¹, Hiroshi Ooyama⁵, Keiko Ooyama⁵, Toru Shimizu⁶, Mitsuo Nagase⁷, Yuji Hidaka⁸, Kimiyoshi Ichida⁹, Ituro Inoue¹⁰, Nariyoshi Shinomiya¹, Hirotaka Matsuo¹¹; Japan Gout Genomics Consortium (Japan Gout)

Affiliations

¹ Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
² Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Aichi, Japan.
³ Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Shizuoka, Japan; Department of Cancer Genome Research, Sasaki Institute, Sasaki Foundation, Tokyo, Japan.
⁴ Department of Medical Biochemistry, Kurume University School of Medicine, Fukuoka, Japan.
⁵ Ryougoku East Gate Clinic, Tokyo, Japan.
⁶ Midorigaoka Hospital, Osaka, Japan; Kyoto Industrial Health Association, Kyoto, Japan.
⁷ Nagase Clinic, Tokyo, Japan.
⁸ Akasaka Central Clinic, Tokyo, Japan.
⁹ Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; Division of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
¹⁰ Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Shizuoka, Japan.
¹¹ Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan. Electronic address: hmatsuo.ndmc@gmail.com.

PMID: 35148957
DOI: 10.1016/j.ymgme.2022.01.100

Abstract

Despite progress in understanding of the genetic basis of gout, the precise factors affecting differences in gout susceptibility among different gout subtypes remain unclear. Using clinically diagnosed gout patients, we conducted a genome-wide meta-analysis of two distinct gout subtypes: the renal overload type and the renal underexcretion type. We provide genetic evidence at a genome-wide level of significance that supports a positive association between ABCG2 dysfunction and acquisition of the renal overload type.

Keywords: ABCG2; GWAS; Gout subtype; ROL type; RUE type; Urate handling.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease*
Gout* / genetics
Humans
Japan
Kidney
Polymorphism, Single Nucleotide