Conventional vs high-frequency ventilation for weaning from total liquid ventilation in lambs

Respir Physiol Neurobiol. 2022 May:299:103867. doi: 10.1016/j.resp.2022.103867. Epub 2022 Feb 8.


Objective: To compare conventional gas ventilation (GV) and high-frequency oscillatory ventilation (HFOV) for weaning from total liquid ventilation (TLV).

Methods: Sixteen lambs were anesthetized. After 1 h of TLV with perflubron (PFOB), they were assigned to either GV or HFOV for 2 h. Oxygen requirements, electrical impedance tomography and videofluoroscopic sequences, and respiratory system compliance were recorded.

Results: The lambs under GV needed less oxygen at 20 min following TLV (40 [25, 45] and 83 [63, 98]%, p = 0.001 under GV and HFOV, respectively). During weaning, tidal volume distribution was increased in the nondependent regions in the GV group compared to baseline (p = 0.046). Furthermore, residual PFOB was observed in the most dependent region. No air was detected by fluoroscopy in that region at the end of expiration in the GV group.

Conclusion: GV offers a transient advantage over HFOV with regards to oxygenation for TLV weaning.

Keywords: Electrical impedance tomography; High-frequency oscillatory ventilation; Lamb; Neonate; Total liquid ventilation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • High-Frequency Ventilation* / methods
  • Liquid Ventilation* / methods
  • Lung
  • Oxygen
  • Pulmonary Gas Exchange
  • Sheep
  • Sheep, Domestic


  • Oxygen