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Review
. 2022 Feb 5:15:413-426.
doi: 10.2147/IDR.S348643. eCollection 2022.

Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes

Ashagrachew Tewabe Yayehrad  1   2 , Gebremariam Birhanu Wondie  1 , Tesfa Marew  1
Affiliations
Review

Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes

Ashagrachew Tewabe Yayehrad et al. Infect Drug Resist. .

Abstract

The percentages of organisms exhibiting antimicrobial resistance, especially resistance to multiple antibiotics, are incessantly increasing. Studies investigated that many bacteria are being resistant to ciprofloxacin. This review addresses the current knowledge on nano-based ciprofloxacin delivery approaches to improve its effectiveness and overcome the resistance issues. Ciprofloxacin delivery can be modified by encapsulating with or incorporating in different polymeric nanoparticles such as chitosan, PLGA, albumin, arginine, and other organic and inorganic nanostructure systems. Most of these nano-approaches are promising as an alternative strategy to improve the therapeutic effectiveness of ciprofloxacin in the future.

Keywords: antimicrobial resistance; ciprofloxacin; ciprofloxacin resistance; nanotechnology.

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Conflict of interest statement

The authors have declared that there is no competing interest.

Figures

Figure 1
Figure 1
Micellar nanosphere encapsulated ciprofloxacin incorporated into contact lens
Figure 2
Figure 2
Arginine grafted mesoporous silica nanoparticle targeting intracellular Salmonella.
Figure 3
Figure 3
Ciprofloxacin-loaded lipid-core nanocapsules and their effects.
See this image and copyright information in PMC

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