Common and differential features of liver and pancreatic cancers: molecular mechanism approach

Gastroenterol Hepatol Bed Bench. 2021 Fall;14(Suppl1):S87-S93.


Aim: The aim of this study was to introduce biomarkers commonly involved in pancreatic cancer metastasis to the liver.

Background: The liver is affected by metastatic disease in pancreatic cancer.

Methods: Two cancer biomarkers were distinguished through a STRING database protein query. The dysregulated proteins of the two cancers were included in 2 networks drawn by Cytoscape software v 3.2.7. 20 top nodes and achieved by the Network analyzer application of Cytoscape based on degree value. The common hub nodes were determined, and action maps were analyzed.

Results: Among 20 hubs of each studied cancer, 18 common hub nodes (90% of hubs) were identified and screened by action maps. Four proteins, AKT1, CDKN2A, ERBB2, and IL6, were identified as common central proteins related to the two studied diseases.

Conclusion: AKT1, CDKN2A, ERBB2, and IL6 are common protein core of liver and pancreatic cancers, while STAT3, CASP3, NOTCH1, and CTNNB1 are possible differential proteins to discriminate these cancers.

Keywords: Biomarker; Ductal adenocarcinoma; Liver cancer; Network analysis; Pancreas.