Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease

Jiahui Hu; Hao Lei; Leiling Liu; Danyan Xu

doi:10.3389/fcell.2022.812368

Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease

Front Cell Dev Biol. 2022 Jan 27:10:812368. doi: 10.3389/fcell.2022.812368. eCollection 2022.

Authors

Jiahui Hu^{1

2

3

4}, Hao Lei^{1

2

3

4}, Leiling Liu^{1

2

3

4}, Danyan Xu^{1

2

3

4}

Affiliations

¹ Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
² Research Institute of Blood Lipid and Atherosclerosis, Central South University, Changsha, China.
³ Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, China.
⁴ Cardiovascular Disease Research Center of Hunan Province, Changsha, China.

Abstract

Calcified aortic valve disease (CAVD) is the most common valvular cardiovascular disease with increasing incidence and mortality. The primary treatment for CAVD is surgical or transcatheter aortic valve replacement and there remains a lack of effective drug treatment. Recently, lipoprotein (a) (Lp(a)) has been considered to play a crucial role in CAVD pathophysiology. Multiple studies have shown that Lp(a) represents an independent risk factor for CAVD. Moreover, Lp(a) mediates the occurrence and development of CAVD by affecting aortic valve endothelial dysfunction, indirectly promoting foam cell formation through oxidized phospholipids (OxPL), inflammation, oxidative stress, and directly promotes valve calcification. However, there is a lack of clinical trials with Lp(a) reduction as a primary endpoint. This review aims to explore the relationship and mechanism between Lp(a) and CAVD, and focuses on the current drugs that can be used as potential therapeutic targets for CAVD.

Keywords: apolipoprotein; autotaxin; calcific aortic valve disease; lipoprotein (a); oxidized phospholipid.

Publication types

Review