Hypersensitivity reactions to COVID-19 vaccines: a case of Eosinophilic pneumonia following Sinovac/CoronaVac vaccination

Eur Ann Allergy Clin Immunol. 2023 Jan;55(1):41-45. doi: 10.23822/EurAnnACI.1764-1489.247. Epub 2022 Feb 11.

Abstract

Hypersensitivity reactions has been reported with COVID-19 vaccines. Acute eosinophilic pneumonia has not been reported yet after Sinovac/CoronaVac vaccine. A 73-year-old woman presented with maculopapular rash, cough and dyspnea following Sinovac/CoronaVac injection. The complete blood count (CBC) indicated eosinophilia and further evaluation of the eosinophilia with CT and bronchoscopy confirmed a diagnosis of acute eosinophilic pneumonia. After methylprednisolone therapy, her rash resolved with marked improvement of the dyspnea. She is still on treatment and on the follow up period, we plan to continue steroid treatment at least 3 months.

Keywords: COVID-19; COVID-19 vaccines; SARS-CoV-2; Sinovac/CoronaVac; eosinophiles; eosinophilic pneumonia; rash.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • COVID-19 Vaccines* / adverse effects
  • COVID-19*
  • Dyspnea
  • Exanthema*
  • Female
  • Humans
  • Hypersensitivity*
  • Pulmonary Eosinophilia* / chemically induced
  • Pulmonary Eosinophilia* / diagnosis
  • Vaccination

Substances

  • COVID-19 Vaccines
  • sinovac COVID-19 vaccine