Nobel somatosensations and pain

Pflugers Arch. 2022 Apr;474(4):405-420. doi: 10.1007/s00424-022-02667-x. Epub 2022 Feb 14.

Abstract

The Nobel prices 2021 for Physiology and Medicine have been awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch", TRPV1 and PIEZO1/2. The present review tells the past history of the capsaicin receptor, covers further selected TRP channels, TRPA1 in particular, and deals with mechanosensitivity in general and mechanical hyperalgesia in particular. Other achievements of the laureates and translational aspects of their work are shortly treated.

Keywords: 50 ion channels; Agonists; Antagonists; GPCRs.

Publication types

  • Review

MeSH terms

  • Capsaicin
  • Humans
  • Hyperalgesia*
  • Ion Channels
  • Nobel Prize
  • Pain*
  • TRPA1 Cation Channel
  • TRPV Cation Channels
  • Temperature

Substances

  • Ion Channels
  • PIEZO1 protein, human
  • TRPA1 Cation Channel
  • TRPV Cation Channels
  • Capsaicin