Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease

Joachim Krebs

doi:10.3390/ijms23031027

Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease

Int J Mol Sci. 2022 Jan 18;23(3):1027. doi: 10.3390/ijms23031027.

Author

Joachim Krebs¹

Affiliation

¹ Department of NMR-Based Structural Biology, Max Planck Institute (MPI) for Biophysical Chemistry, 37077 Gottingen, Germany.

Abstract

In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.

Keywords: PMCA; calmodulin; microdomains; plasma membrane calcium pump; spliced isoforms.

Publication types

Review

MeSH terms

Cell Membrane / metabolism
Gene Expression Regulation
Humans
Models, Molecular
Plasma Membrane Calcium-Transporting ATPases / chemistry*
Plasma Membrane Calcium-Transporting ATPases / genetics
Plasma Membrane Calcium-Transporting ATPases / metabolism*
Protein Conformation
RNA Splicing

Substances

Plasma Membrane Calcium-Transporting ATPases