Maresin-1 and Inflammatory Disease

Int J Mol Sci. 2022 Jan 25;23(3):1367. doi: 10.3390/ijms23031367.


Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified. Dietary foods are an essential daily lifestyle that influences various human physiological processes and pathological conditions. Especially, omega-3 fatty acids in the diet ameliorate chronic inflammatory skin diseases. Recent studies have identified that omega-3 fatty acid derivatives, such as the resolvin series, showed strong anti-inflammatory actions in various inflammatory diseases. Maresin-1 is a derivative of one of the representative omega-3 fatty acids, i.e., docosahexaenoic acid (DHA), and has shown beneficial action in inflammatory disease models. In this review, we summarize the detailed actions of maresin-1 in immune cells and inflammatory diseases.

Keywords: Keywords: ω-3 polyunsaturated fatty acids; inflammatory diseases; maresin-1.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Diet
  • Docosahexaenoic Acids / analogs & derivatives
  • Docosahexaenoic Acids / metabolism
  • Docosahexaenoic Acids / pharmacology*
  • Eicosapentaenoic Acid / pharmacology
  • Fatty Acids, Omega-3 / pharmacology
  • Humans
  • Inflammation / diet therapy*


  • 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
  • Anti-Inflammatory Agents
  • Fatty Acids, Omega-3
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid