Tiopronin-nephropathy: clinical, pathological, immunological and immunogenetic characteristics

Clin Exp Rheumatol. Jan-Mar 1986;4(1):9-15.


Nine patients who developed proteinuria while on Tiopronin (a D-Penicillamine-like drug) have been studied. Nephrotic syndrome was observed in six cases. Immunologic analysis revealed a high frequency of ANA positivity and RF seronegativity by the time nephropathy appeared. Six patients were biopsied. Immunofluorescence, electron and light microscopy studies showed: glomerulonephritis with segmental deposits in the mesangium and along the capillary walls in one patient, mesangioprolipherative glomerulonephritis in one case and stage 1 membranous glomerulonephritis in four cases. Immunogenetic typing disclosed a strong association with B35-Cw4 class I antigens.

MeSH terms

  • Adult
  • Aged
  • Amino Acids, Sulfur / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / immunology
  • Biopsy, Needle
  • Capillaries / ultrastructure
  • Complement C3 / analysis
  • Complement C4 / analysis
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulins / analysis
  • Kidney Glomerulus / immunology
  • Kidney Glomerulus / ultrastructure
  • Microscopy, Electron
  • Middle Aged
  • Proteinuria*
  • Renal Circulation
  • Tiopronin / adverse effects*
  • Tiopronin / therapeutic use


  • Amino Acids, Sulfur
  • Complement C3
  • Complement C4
  • Immunoglobulins
  • Tiopronin