Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model

Signal Transduct Target Ther. 2022 Feb 14;7(1):47. doi: 10.1038/s41392-021-00860-5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Body Weight / drug effects
  • COVID-19 / genetics
  • COVID-19 / immunology
  • COVID-19 / virology
  • COVID-19 Drug Treatment*
  • Cricetulus
  • Cytokine Release Syndrome / drug therapy*
  • Cytokine Release Syndrome / genetics
  • Cytokine Release Syndrome / immunology
  • Cytokine Release Syndrome / virology
  • Disease Models, Animal
  • Gene Expression / drug effects*
  • Humans
  • Interferon-gamma / genetics
  • Interferon-gamma / immunology
  • Interleukin-10 / genetics
  • Interleukin-10 / immunology
  • Interleukin-6 / genetics
  • Interleukin-6 / immunology
  • Lung / drug effects
  • Lung / immunology
  • Lung / virology
  • Male
  • Progesterone / pharmacology*
  • SARS-CoV-2 / drug effects*
  • SARS-CoV-2 / growth & development
  • SARS-CoV-2 / immunology
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Antiviral Agents
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Progesterone
  • Interferon-gamma