A randomized double-blind placebo-controlled study of dipyrone and aspirin in post-operative orthopaedic patients

J Int Med Res. 1986;14(2):63-6. doi: 10.1177/030006058601400202.


Two hundred and fifty-four patients with post-operative pain following closed reduction of fractured long bones completed a double-blind study of dipyrone and aspirin. Compared with placebo both active treatments produced significant relief of pain, which was apparent 30 minutes after ingestion and was maintained for the 6-hour duration of the study. Dipyrone 500 mg produced significantly greater pain relief than aspirin 500 mg. Both drugs were generally well tolerated.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aminopyrine / analogs & derivatives*
  • Aspirin / therapeutic use*
  • Clinical Trials as Topic
  • Dipyrone / therapeutic use*
  • Double-Blind Method
  • Female
  • Fractures, Bone / surgery
  • Humans
  • Male
  • Pain, Postoperative / drug therapy*
  • Placebos
  • Random Allocation
  • Time Factors


  • Placebos
  • Aminopyrine
  • Dipyrone
  • Aspirin