Plasma fructose, uric acid, and inorganic phosphorus responses of hyperinsulinemic men fed fructose

J Am Coll Nutr. 1986;5(1):61-8. doi: 10.1080/07315724.1986.10720113.

Abstract

We fed 12 men with abnormally high insulin responses to a sucrose load and 12 controls normal diets containing 0, 7.5, or 15% of the calories as pure fructose for 5 weeks each in a crossover design. Purified wheat starch replaced the fructose in the 0 and 7.5% diets. The two groups were matched for age, height, and weight. At the beginning of the study and at the end of each of the three 5-week periods, plasma responses to a sucrose load (2 gm/kg body weight) were measured. Initially there were no significant differences in the plasma fructose, uric acid, or inorganic phosphorus responses of the two groups. Plasma fructose responses to a sucrose load were significantly higher after the men consumed the 7.5 and 15% fructose diets than after the 0% diet. Uric acid responses tended to be greater in the hyperinsulinemic men than in controls and increased as the levels of fructose in the diet increased. The inorganic phosphorus levels after a sucrose load were higher in the hyperinsulinemic men than in controls when they consumed the 7.5 and 15% fructose diets. These results indicate that moderate levels of dietary fructose can affect plasma fructose, uric acid, and inorganic phosphorus levels, especially in hyperinsulinemic men.

MeSH terms

  • Adult
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / pharmacology
  • Fructose / administration & dosage
  • Fructose / blood
  • Fructose / pharmacology*
  • Humans
  • Insulin / blood*
  • Male
  • Phosphorus / blood*
  • Sucrose
  • Uric Acid / blood*

Substances

  • Dietary Carbohydrates
  • Insulin
  • Uric Acid
  • Phosphorus
  • Fructose
  • Sucrose