Historical introduction: the Italian contribution to the discovery of 5-hydroxytryptamine (enteramine, serotonin)

J Hypertens Suppl. 1986 Apr;4(1):S3-5.


In 1949-1951 two independent lines of research led to the discovery and elucidation of the structure of serotonin and enteramine, and their identification with 5-hydroxytryptamine. This is briefly described, with emphasis on the Italian contribution to the solution of the problem.

Publication types

  • Historical Article

MeSH terms

  • Chemistry
  • Enterochromaffin Cells / analysis
  • History, 20th Century
  • Italy
  • Serotonin / history*
  • Serotonin / isolation & purification
  • Serotonin / therapeutic use


  • Serotonin