α-Synuclein in Parkinson's disease and advances in detection

Clin Chim Acta. 2022 Apr 1;529:76-86. doi: 10.1016/j.cca.2022.02.006. Epub 2022 Feb 14.

Abstract

Parkinson's disease (PD) is a threatening neurodegenerative disorder that seriously affects patients' life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (α-Syn) to PD. α-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic process of α-Syn based on recent researches, outlines and compares commonly used analysis and detection technologies of α-Syn. Specifically, the detection of α-Syn by new electrochemical, photochemical, and crystal biosensors is mainly examined. Furthermore, the speculation of future study orientation is discussed, which provides reference for the further research and application of α-Syn as biomarker.

Keywords: Alpha-synuclein; Biosensor; Detection method; Parkinson's disease; Pathogenic process.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Biosensing Techniques*
  • Humans
  • Parkinson Disease* / diagnosis
  • Parkinson Disease* / pathology
  • alpha-Synuclein / analysis

Substances

  • Biomarkers
  • alpha-Synuclein