[The role of sex hormones in the pathogenesis of melasma]

Ugeskr Laeger. 2022 Feb 7;184(6):V10210769.
[Article in Danish]


Facial melasma is a common, acquired, skin condition, which typically presents itself as symmetric hyperpigmentation. It is multifactorial, and hormonal influence is one of the most dominant aetiologies. This review investigates the link between sex hormones and facial melasma. Ten studies were identified, and they overall conclude, that oestrogens play a role in the pathogenesis of melasma in females but not in males. Progesterone, follicle-stimulating hormone and lutropin play no significant role in males or females, while testosterone possibly plays a role in males.

Publication types

  • Review

MeSH terms

  • Female
  • Gonadal Steroid Hormones
  • Humans
  • Hyperpigmentation* / complications
  • Male
  • Melanosis* / etiology
  • Melanosis* / pathology
  • Progesterone


  • Gonadal Steroid Hormones
  • Progesterone