International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Clin Gastroenterol Hepatol. 2022 Nov;20(11):2474-2484.e3. doi: 10.1016/j.cgh.2022.02.017. Epub 2022 Feb 16.


Background & aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term "eosinophilic gastroenteritis," limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature.

Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement.

Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. "EGID" was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an "Eo" abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term "eosinophilic gastroenteritis" is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas.

Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than "eosinophilic gastroenteritis," and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

Keywords: Classification; Delphi; Eosinophilic Gastroenteritis; Eosinophilic Gastrointestinal Disease; Nomenclature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Consensus
  • Enteritis* / complications
  • Enteritis* / diagnosis
  • Eosinophilia* / complications
  • Eosinophilia* / diagnosis
  • Eosinophilic Esophagitis* / complications
  • Gastritis* / complications
  • Gastritis* / diagnosis
  • Humans

Supplementary concepts

  • Eosinophilic enteropathy