BMP10 expression in the adult rat central nervous system

Chikara Ogawa; Sumiko Mikawa; Shuo Li; Yutaro Hayashi; Kazuma Masumoto; Kohji Sato

doi:10.1016/j.jchemneu.2022.102084

BMP10 expression in the adult rat central nervous system

J Chem Neuroanat. 2022 Apr:121:102084. doi: 10.1016/j.jchemneu.2022.102084. Epub 2022 Feb 16.

Authors

Chikara Ogawa¹, Sumiko Mikawa², Shuo Li³, Yutaro Hayashi⁴, Kazuma Masumoto⁴, Kohji Sato⁵

Affiliations

¹ Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan; Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
² Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
³ Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan; Department of Orthopedic Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan.
⁴ Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
⁵ Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan. Electronic address: ksato@hama-med.ac.jp.

PMID: 35182716
DOI: 10.1016/j.jchemneu.2022.102084

Abstract

Bone morphogenetic protein 10 (BMP10), is a member of the transforming growth factor β (TGFβ) superfamily. Although BMP10 plays pivotal roles during development, including vascular development and cardiogenesis, little information is available for BMP10 expression in the central nervous system (CNS). We, thus, investigated BMP10 expression in the adult rat CNS using immunohistochemistry. BMP10 was intensely expressed in most neurons and their axons. Furthermore, we found that astrocytes and ependymal cells also express BMP10 protein. These data indicate that BMP10 is widely expressed throughout the adult CNS, and this abundant expression strongly supports the idea that BMP10 also plays important roles in the adult CNS.

Keywords: Axon; BMP10; Immunohistochemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Morphogenetic Proteins / metabolism
Brain* / metabolism
Central Nervous System
Neurons* / metabolism
Rats
Rats, Wistar

Substances

Bone Morphogenetic Proteins