Case Report: Cerebral Nocardiosis Caused by Nocardia cyriacigeorgica Detected by Metagenomics in an Apparently Immunocompetent Patient

Front Immunol. 2022 Feb 3:13:719124. doi: 10.3389/fimmu.2022.719124. eCollection 2022.

Abstract

We report a case of meningoencephalitis due to Nocardia cyriacigeorgica diagnosed with metagenomics, while all the standard methods were negative. This diagnosis made adaptation of antimicrobial treatment possible and led to the discovery of a rare, acquired immunodeficiency syndrome.

Keywords: Nocardia; infection; meningoencephalitis; metagenomic; molecular biology.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / diagnosis*
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Metagenomics*
  • Nocardia / genetics*
  • Nocardia Infections / diagnosis*
  • Nocardia Infections / drug therapy
  • Tomography, X-Ray Computed

Substances

  • Anti-Bacterial Agents

Supplementary concepts

  • Nocardia cyriacigeorgica