Enucleation vs cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body

Arch Ophthalmol. 1986 May;104(5):655-61. doi: 10.1001/archopht.1986.01050170045019.


Clinical risk factors were assessed prospectively in a nonrandomized concurrent observational study of 237 patients with posterior uveal malignant melanoma. One hundred forty of these patients were treated with enucleation, and 97 underwent cobalt plaque radiotherapy. Tumor size and location of the anterior tumor margin proved to be the most significant clinical risk factors for death from metastatic melanoma. When Cox proportional hazards modeling was used to adjust for recognized intergroup differences in risk factors, the effect of therapy (enucleation vs cobalt plaque radiotherapy) on survival time was not statistically significant. We discuss the implications of this study for a randomized clinical trial of enucleation vs cobalt plaque therapy or comparable forms of irradiation.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Choroid Neoplasms / mortality
  • Choroid Neoplasms / radiotherapy
  • Choroid Neoplasms / surgery*
  • Ciliary Body*
  • Clinical Trials as Topic
  • Cobalt Radioisotopes / therapeutic use*
  • Female
  • Humans
  • Male
  • Melanoma / mortality
  • Melanoma / radiotherapy
  • Melanoma / surgery*
  • Middle Aged
  • Ophthalmologic Surgical Procedures*
  • Prospective Studies
  • Radiography
  • Risk
  • Uveal Neoplasms / diagnostic imaging
  • Uveal Neoplasms / mortality
  • Uveal Neoplasms / surgery*


  • Cobalt Radioisotopes