Factors affecting drug biotransformation

Clin Biochem. 1986 Apr;19(2):72-5. doi: 10.1016/s0009-9120(86)80051-0.

Abstract

Biotransformation of drugs to polar metabolites is a key step in the termination of action and the elimination of drugs used in therapeutics. A large number of factors, including infection, alter the basal rates of drug metabolism and cause a number of untoward effects and drug interactions. Although a number of techniques have been attempted, there appears to be no easy way to determine the capacity of an individual to metabolize a specific drug and to tailor drug dosage to that individual.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biotransformation
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Humans
  • Infections / metabolism
  • Kinetics
  • Liver / enzymology
  • Liver / metabolism
  • Metabolic Clearance Rate
  • Pharmaceutical Preparations / metabolism*

Substances

  • Pharmaceutical Preparations
  • Cytochrome P-450 Enzyme System