Lot-to-lot reagent verification: challenges and possible solutions

Clin Chem Lab Med. 2022 Feb 22;60(5):675-680. doi: 10.1515/cclm-2022-0092. Print 2022 Apr 26.


Lot-to-lot verification is an important laboratory activity that is performed to monitor the consistency of analytical performance over time. In this opinion paper, the concept, clinical impact, challenges and potential solutions for lot-to-lot verification are exained.

Keywords: analytical variation; between-lot verification; external quality assurance; lot-to-lot verification; moving averages; patient-based quality control; quality control; reagent verification.

MeSH terms

  • Humans
  • Laboratories*
  • Quality Control
  • Reagent Kits, Diagnostic*


  • Reagent Kits, Diagnostic