Asperbenzophenone A and Versicolamide C, New Fungal Metabolites from the Soft Coral Derived Aspergillus sp. SCSIO 41036

Chem Biodivers. 2022 Mar;19(3):e202100925. doi: 10.1002/cbdv.202100925. Epub 2022 Feb 22.


Two new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide-inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti-acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC50 value of 157.8 μM.

Keywords: Aspergillus; acetylcholinesterase inhibitory; nitric oxide; soft coral.

MeSH terms

  • Animals
  • Anthozoa*
  • Aspergillus / chemistry
  • Fungi
  • Indole Alkaloids


  • Indole Alkaloids
  • versicolamide C