Advancing Clinical Trials in Nursing Homes: A Proposed Roadmap to Success

J Am Geriatr Soc. 2022 Mar;70(3):701-708. doi: 10.1111/jgs.17696. Epub 2022 Feb 23.

Abstract

An effective clinical research effort in nursing homes to address prevention and treatment of COVID-19 faced overwhelming challenges. Under the Health Care Systems Research Network-Older Americans Independence Centers AGING Initiative, a multidisciplinary Stakeholder Advisory Panel was convened to develop recommendations to improve the capability of the clinical research enterprise in US nursing homes. The Panel considered the nursing home as a setting for clinical trials, reviewed the current state of clinical trials in nursing homes, and ultimately developed recommendations for the establishment of a nursing home clinical trials research network that would be centrally supported and administered. This report summarizes the Panel's recommendations, which were developed in alignment with the following core principles: build on available research infrastructure where appropriate; leverage existing productive partnerships of researchers with groups of nursing homes and nursing home corporations; encompass both efficacy and effectiveness clinical trials; be responsive to a broad range of stakeholders including nursing home residents and their care partners; be relevant to an expansive range of clinical and health care delivery research questions; be able to pivot as necessary to changing research priorities and circumstances; create a pathway for industry-sponsored research as appropriate; invest in strategies to increase diversity in study populations and the research workforce; and foster the development of the next generation of nursing home researchers.

Keywords: COVID-19; clinical trials; long-term care; nursing homes; pandemic.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • COVID-19 / epidemiology
  • Clinical Trials as Topic / organization & administration*
  • Female
  • Humans
  • Male
  • Nursing Homes / organization & administration*
  • Pandemics
  • SARS-CoV-2
  • United States / epidemiology