Abstract
1 Clobazam was compared with placebo and diazepam in 45 double-blind studies. 2 Clobazam dosage ranged from 5 mg daily (paediatric patients) to 120 mg daily (psychiatric in-patients). Usual daily dosage in out-patient therapy ranged from 20-30 mg clobazam. 3 Treatment duration varied from a few days up to 3.5 years. The usual duration of treatment was 2-4 weeks. 4 Clobazam was shown to be an efficacious and well tolerated anxiolytic agent in various neurotic and psychosomatic disorders. 5 Dosages showing distinct anxiolytic effects in out-patient therapy did not impair psychomotor performance.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adult
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Alcoholism / drug therapy
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Anti-Anxiety Agents / adverse effects
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Anti-Anxiety Agents / therapeutic use*
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Anxiety / drug therapy
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Anxiety Disorders / drug therapy
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Child
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Clinical Trials as Topic
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Diazepam / adverse effects
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Diazepam / therapeutic use
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Double-Blind Method
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Female
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Humans
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Male
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Motor Skills / drug effects
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Psychophysiologic Disorders / drug therapy
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Psychotic Disorders / drug therapy
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Sleep Wake Disorders / drug therapy
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Substance Withdrawal Syndrome / drug therapy
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Time Factors
Substances
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Anti-Anxiety Agents
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Diazepam