Calciphylaxis: Treatment and outlook-CME part II

J Am Acad Dermatol. 2022 May;86(5):985-992. doi: 10.1016/j.jaad.2021.10.063. Epub 2022 Feb 22.


Calciphylaxis is a rare and devastating condition with important systemic ramifications. This second-part of our CME aims to educate the practicing dermatologist on the current standard of care once a diagnosis of calciphylaxis is confirmed or highly suspected. The key pathologic findings, as well as the role and limitations of biopsy, are reviewed. We aim to guide readers through the complex hospitalization and posthospitalization management of these medically vulnerable patients. Collaboration with other specialists will be discussed. Experimental and developing treatments are discussed, and the outlook of the condition is reported.

Keywords: ESRD; calciphylaxis; calcium; clinical trials; palliative care; sodium thiosulfate.

Publication types

  • Review

MeSH terms

  • Calciphylaxis* / diagnosis
  • Calciphylaxis* / etiology
  • Calciphylaxis* / therapy
  • Female
  • Humans
  • Kidney Failure, Chronic* / therapy
  • Male
  • Thiosulfates


  • Thiosulfates