Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties

Pharm Weekbl Sci. 1986 Apr 25;8(2):109-33. doi: 10.1007/BF02086146.


A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.

Publication types

  • Review

MeSH terms

  • Adsorption
  • Antibiotics, Antineoplastic / analysis*
  • Chemical Phenomena
  • Chemistry
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Metals / analysis
  • Naphthacenes / analysis
  • Solubility
  • Spectrophotometry


  • Antibiotics, Antineoplastic
  • Metals
  • Naphthacenes