Baclofen trial in six myotonic dystrophy patients

Acta Neurol Scand. 1978 Mar;57(3):232-8. doi: 10.1111/j.1600-0404.1978.tb05870.x.

Abstract

Six young adult patients with grade I myotonic dystrophy and a complaint of daytime somnolence underwent 36-hour polygraphic monitoring, dynamometric and electromyographic studies before and under baclofen (60 mg/daily). Patients with the most severe daytime sleepiness had pathologic Sleep Apnea Indexes. After 6 weeks' ingestion of baclofen, no subjective or objective effect on patient symptomatology was found.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aminobutyrates / therapeutic use*
  • Baclofen / therapeutic use*
  • Clinical Trials as Topic
  • Drug Evaluation
  • Humans
  • Male
  • Monitoring, Physiologic
  • Myotonic Dystrophy / drug therapy*
  • Sleep Wake Disorders / drug therapy

Substances

  • Aminobutyrates
  • Baclofen