Differences of Sex Development: What Neonatologists Need to Know

Natalie G Allen; Kanthi Bangalore Krishna; Peter A Lee

doi:10.1016/j.clp.2021.11.013

Differences of Sex Development: What Neonatologists Need to Know

Clin Perinatol. 2022 Mar;49(1):207-218. doi: 10.1016/j.clp.2021.11.013.

Authors

Natalie G Allen¹, Kanthi Bangalore Krishna², Peter A Lee²

Affiliations

¹ Division of Endocrinology and Diabetes, Department of Pediatrics, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA. Electronic address: nallen4@pennstatehealth.psu.
² Division of Endocrinology and Diabetes, Department of Pediatrics, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

PMID: 35210002
DOI: 10.1016/j.clp.2021.11.013

Abstract

Differences of sex development (DSD) refer to rare conditions in which an individual's sex development is different from typical male or female development. The neonatologist is often the first health care provider to interact with parents of newborns with DSD and must be familiar with the approach to patients with DSD. In this article, we discuss definition of DSD, initial workup of the patient with DSD, terminology, and controversies in care.

Keywords: Atypical genitalia; Differences of sex development (DSD); Variations of sex development.

Publication types

Review

MeSH terms

Disorders of Sex Development* / diagnosis
Disorders of Sex Development* / therapy
Female
Humans
Infant, Newborn
Male
Neonatologists
Parents