Clozapine in the treatment of tremor

Acta Neurol Scand. 1986 Mar;73(3):295-7. doi: 10.1111/j.1600-0404.1986.tb03279.x.


In an open trial 25 tremor patients were treated with clozapine in small doses (18-75 mg per day). The effect was measured with a new movement analyzer. Nine of 12 essential tremor patients were greatly improved. In six of nine patients with Parkinson tremor and in two combined essential tremor/Parkinson tremor patients tremor almost disappeared. Sedation is a major side effect, but decreases in most patients with time. The risk of agranulocytosis makes blood control necessary.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Alcoholism / physiopathology
  • Clinical Trials as Topic
  • Clozapine / therapeutic use*
  • Dibenzazepines / therapeutic use*
  • Double-Blind Method
  • Humans
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology
  • Tremor / drug therapy*
  • Tremor / etiology
  • Tremor / physiopathology


  • Dibenzazepines
  • Clozapine