Pharmacokinetics of antiarrhythmic drugs

Am J Cardiol. 1978 May 22;41(6):986-95. doi: 10.1016/0002-9149(78)90851-2.

Abstract

A knowledge of the determinants of the plasma concentrations of antiarrhythmic drugs is important because variation in plasma levels is often greater than the desired therapeutic range. The basic principles of pharmacokinetics are outlined and their application to the design of dosage regimens described. These principles are illustrated in a review of the pharmacokinetics of lidocaine and its congeners, procainamide and its active metabolite (N-acetylprocainamide), quindine, disopyramide, phenytoin and propranolol, with particular emphasis of the factors that contribute to altered disposition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Administration, Oral
  • Anti-Arrhythmia Agents / pharmacology*
  • Anti-Arrhythmia Agents / therapeutic use
  • Disopyramide / pharmacology
  • Dose-Response Relationship, Drug
  • Glycine / metabolism
  • Half-Life
  • Injections, Intravenous
  • Kinetics
  • Lidocaine / metabolism
  • Procainamide / pharmacology
  • Quinidine / pharmacology

Substances

  • Anti-Arrhythmia Agents
  • Lidocaine
  • Disopyramide
  • Quinidine
  • Procainamide
  • Glycine