Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis

Arzneimittelforschung. 1986 Apr;36(4):715-7.

Abstract

In vitro and ex vivo effects of 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (diferuloylmethane, curcumin) and acetylsalicylic acid (ASA) on the synthesis of prostacyclin (PGI2) and on platelet aggregation has been studied in rat. Both drugs inhibited adenosine diphosphate (ADP)-, epinephrine (adrenaline)- and collagen-induced platelet aggregation in monkey plasma. Pretreatment with ASA (25-100 mg/kg), but not curcumin (100-300 mg/kg), inhibited PGI2 synthesis in rat aorta. In the in vitro system, too, curcumin caused a slight increase in the synthesis of PGI2, while ASA inhibited it. Curcumin may, therefore, be preferable in patients prone to vascular thrombosis and requiring antiarthritic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Animals
  • Aorta, Thoracic / metabolism
  • Aspirin / pharmacology
  • Catechols / pharmacology*
  • Collagen / pharmacology
  • Curcumin / pharmacology*
  • Epinephrine / pharmacology
  • Epoprostenol / biosynthesis*
  • In Vitro Techniques
  • Macaca mulatta
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / metabolism*
  • Platelet Aggregation / drug effects*
  • Rats

Substances

  • Catechols
  • Adenosine Diphosphate
  • Collagen
  • Epoprostenol
  • Curcumin
  • Aspirin
  • Epinephrine