Influenza immunization in systemic lupus eruthematosus. A double-blind trial

Ann Intern Med. 1978 Jun;88(6):729-34. doi: 10.7326/0003-4819-88-6-729.


Forty patients with systemic lupus erythematosus randomly received inactivated bivalent (A/NJ and A/Victoria) influenza vaccine or saline in a double-blind study. During 20 weeks of follow-up, no deterioration in major organ function or increase in disease flares was observed in the immunized group as compared with the group that received saline. Preimmunization antibody titers to A/Victoria were lower in the 40 patients with lupus erythematosus than in age-matched control subjects. Response to immunization, as measured by serum antibody titers, was also lower in the patients with lupus erythematosus, indicating that immune responses must be evaluated on an individual patient basis. Nevertheless, influenza vaccination can be safely carried out in patients with systemic lupus erythematosus.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Antibodies, Viral / analysis
  • Antibody Formation / drug effects
  • Clinical Trials as Topic
  • Complement C3 / metabolism
  • DNA / metabolism
  • Double-Blind Method
  • Female
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Influenza Vaccines* / adverse effects
  • Influenza, Human / prevention & control*
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Prednisone / pharmacology
  • Recurrence
  • Vaccination* / adverse effects


  • Antibodies, Viral
  • Complement C3
  • Immunosuppressive Agents
  • Influenza Vaccines
  • DNA
  • Prednisone