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. 2022 Feb 10:9:822557.
doi: 10.3389/fnut.2022.822557. eCollection 2022.

Caffeine, Coffee, Tea and Risk of Rheumatoid Arthritis: Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies

Farzaneh Asoudeh  1 , Fatemeh Dashti  1 , Ahmad Jayedi  2 , Amirhossein Hemmati  1 , Abdulmannan Fadel  3 , Hamed Mohammadi  1
Affiliations

Caffeine, Coffee, Tea and Risk of Rheumatoid Arthritis: Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies

Farzaneh Asoudeh et al. Front Nutr. .

Abstract

Objective: Prospective cohort studies on coffee, tea and caffeine in relation to the risk of rheumatoid arthritis (RA) have shown conflicting results. The aim of this study was to conduct a dose-response meta-analysis of cohort studies on the association between dietary caffeine, different types of coffee and tea consumption and the risk of RA.

Methods: PubMed/Medline, Scopus and EMBASE were searched up to July 2021 to identify relevant studies that had considered different types of coffee (caffeinated or decaffeinated), tea or caffeine exposure with RA as the main, or one of the, outcome(s). Two authors independently screened 742 publications. Finally, five prospective cohort studies were included in our meta-analysis. Pooled relative risks (RRs) were calculated by using a fixed-effects model. We also performed linear and non-linear dose-response analyses to examine the dose-response relations.

Results: Comparing extreme categories, we found a positive, significant association between coffee (RR: 1.30; 95% CI: 1.04-1.62; I 2 = 0%, n = 5) and decaffeinated coffee (RR: 1.89; 95% CI: 1.35-2.65; I 2 = 38.1%, n =3) consumption and risk of RA. One additional cup of coffee consumed per day was associated with an increased risk of RA by 6% (95% CI: 1.02-1.10; I 2 = 0%). This increase in the risk of RA for one cup/d of decaffeinated coffee was 11% (95% CI: 1.05-1.18; I 2 = 38). No significant association was observed between caffeinated coffee, tea or caffeine intake and the risk of RA.

Conclusion: We found that a higher intake of coffee and decaffeinated coffee was associated with increased risk of RA. No significant association between caffeinated coffee, tea or caffeine intake and the risk of RA was observed.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227665, identifier: CRD42021227665.

Keywords: caffeine; coffee; meta-analysis; rheumatoid arthritis; tea.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Study selection process.
Figure 2
Figure 2
Forest plots showing relative risks of developing rheumatoid arthritis for highest vs. lowest categories of (A) coffee intake, (B) caffeinated coffee intake, (C) decaffeinated coffee intake, and (D) caffeine intake.
Figure 3
Figure 3
Forest plots showing linear dose-response associations for each one cup/day increase of (A) coffee intake, (B) caffeinated coffee intake, (C) decaffeinated coffee intake, and (D) each 200 mg/d increase of caffeine intake with risk of rheumatoid arthritis.
Figure 4
Figure 4
Nonlinear dose-response associations of (A) coffee intake, (B) caffeinated coffee intake, (C) decaffeinated coffee intake, (D) caffeine intake and risk of rheumatoid arthritis.
Figure 5
Figure 5
Forest plots showing relative risks of developing rheumatoid arthritis for (A) highest vs. lowest categories of tea intake and (B) linear dose-response association for each one cup/day increase of tea intake.
Figure 6
Figure 6
Non-linear dose-response association of tea intake and risk of rheumatoid arthritis.
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