Prescribing Nirmatrelvir-Ritonavir: How to Recognize and Manage Drug-Drug Interactions

Ann Intern Med. 2022 May;175(5):744-746. doi: 10.7326/M22-0281. Epub 2022 Mar 1.


Nirmatrelvir–ritonavir (NMV/r) is now being used to treat high-risk patients with mild to moderate COVID-19. This article provides advice to clinicians regarding recognition of medications likely to interact with NMV/r and suggests approaches to managing such drug–drug interactions. An algorithm is provided to assist in decision making.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Drug Interactions
  • Humans
  • Ritonavir* / therapeutic use
  • SARS-CoV-2


  • Ritonavir