Subtypes of Alzheimer's disease: questions, controversy, and meaning

Jacob W Vogel; Oskar Hansson

doi:10.1016/j.tins.2022.02.001

Subtypes of Alzheimer's disease: questions, controversy, and meaning

Trends Neurosci. 2022 May;45(5):342-345. doi: 10.1016/j.tins.2022.02.001. Epub 2022 Feb 25.

Authors

Jacob W Vogel¹, Oskar Hansson²

Affiliations

¹ Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jacob.vogel@pennmedicine.upenn.edu.
² Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden. Electronic address: oskar.hansson@med.lu.se.

Abstract

The distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes a diverse array of syndromes. This forum article provides a brief overview of key controversies in untangling the complexity of AD subtypes, explores potential causes of AD variability in the population, and discusses clinical relevance and future directions of research into AD heterogeneity.

Keywords: atypical; controversy; heterogeneity; pathology; tau; variants.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / pathology
Humans
tau Proteins

Substances

tau Proteins

Grants and funding

T32 MH019112/MH/NIMH NIH HHS/United States