Nine new sesquiterpenes from Curcuma wenyujin rhizomes

Fitoterapia. 2022 Apr:158:105167. doi: 10.1016/j.fitote.2022.105167. Epub 2022 Feb 25.

Abstract

Nine new sesquiterpenes wenyujinones A-I (1-9), along with ten known ones (10-19), were isolated from the rhizomes of Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin). The chemical structures of compounds 1-9 were elucidated by NMR spectroscopic and mass spectrometric data, electronic circular dichroism (ECD) spectra analysis. Furthermore, all compounds were evaluated for the protective effects against hydrogen peroxide (H2O2)-induced injury in human hepatic L02 cells, for the inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells, and for their cytotoxicity against three human cancer cell lines A549, HL60, and MCF7 in vitro. As a result, compounds 2, 4, 14 markedly weakened the oxidative damage induced by H2O2 in L02 cells via strengthening the cell viability.

Keywords: Curcuma wenyujin; Hepatoprotective activity; Sesquiterpenes; Structure determination.

MeSH terms

  • Curcuma* / chemistry
  • Humans
  • Hydrogen Peroxide / analysis
  • Molecular Structure
  • Rhizome / chemistry
  • Sesquiterpenes* / chemistry

Substances

  • Sesquiterpenes
  • Hydrogen Peroxide