A channel mechanism for electrogenic ion pumps

Biochim Biophys Acta. 1979 Mar 23;552(1):143-61. doi: 10.1016/0005-2736(79)90253-0.

Abstract

A model of active ion transport is analyzed in which an essential part of the pumps molecule is an ion channel. Ion translocation in the channel is described as a series of jumps between binding sites which are separated by energy barriers. Pumping action results from a transient energy-dependent modification of the barrier structure of the channel and requires only minor conformational changes of the pump molecule. This model is applied to the light-driven proton pump of Halobacterium and to redox-coupled proton pumps in the mitochondrial respiratory chain. Similar considerations may be used to describe ATP-dependent ion transport.

MeSH terms

  • Biological Transport, Active*
  • Electron Transport
  • Energy Transfer
  • Halobacterium / metabolism
  • Hydrogen-Ion Concentration
  • Ion Channels / metabolism*
  • Mathematics
  • Mitochondria / metabolism
  • Oxidation-Reduction
  • Oxygen Consumption
  • Thermodynamics

Substances

  • Ion Channels