Recurrent Urinary Tract Infection in Young Diabetics: Reason to Look Beyond the Pancreas!

Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):1176-1179. doi: 10.4103/1319-2442.338295.


Wolfram syndrome (WFS) is a rare autosomal recessive disorder which manifests with diabetes mellitus, diabetes insipidus (DI), optic atrophy, and deafness. Central DI is a late presentation of the disease which may rarely present with renal tract anomalies and recurrent urinary infections instead of classical symptoms. We report a family of three siblings with WFS with early onset of central DI and renal tract abnormalities indicating need to suspect and manage these conditions early.

Publication types

  • Case Reports

MeSH terms

  • Diabetes Insipidus*
  • Humans
  • Optic Atrophy* / diagnosis
  • Pancreas
  • Urinary Tract Infections* / complications
  • Urinary Tract Infections* / diagnosis
  • Wolfram Syndrome* / diagnosis